Effect of melittin on mice stomach
Saudi J Biol Sci, 2014 Jan;21(1):99-108
Melittin, the main bee venom component, has many positive
biological effects and a relatively low toxicity in various cell types.
However, there is no evidence of the effect of melittin on gastrointestinal
cells.
In the present study, we investigated the histological and
immuonohistochemical effects of melittin on mice stomach. Adult male mice
(Albino Swiss) were randomly divided into two groups (7 mice for each group):
control group and melittin only treated group (10 and 40 μg/kg). These mice
were sacrificed, then samples from the stomach were collected and prepared for
histopathological studies by using alcian blue stain and immuonohistochemical
studies by using smooth muscle actin (SMA) antibody. Treatment with melittin
alone do not cause any harmful effect on the stomach tissue where the
microscopic examination of Alcian blue stained section showed the normal
distribution of the mucous secreting cells of the stomach tissues. On other
hand, no changes were observed on smooth muscle cells.
This study demonstrated the safety of using melittin on
gastrointestinal tissues if used in definite dose and for suitable duration,
which offers an opportunity for its use as a treatment for many diseases of the
gastrointestinal tract.
No comments:
Post a Comment